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Reversible Brain Shrinkage in Abstinent Alcoholics, Measured by MRI Neuroradiology 30:385-389, Schroth,G.,et al, 1988 See this aricle in Pubmed Article Abstract Magnetic resonance imaging of the intracranial CSF volume was compared before and after 5 weeks of confirmed abstinence in 9 alcohol-dependent patients.All patients showed a highly significant reduction in CSF volume in accordance with reexpansion of the brain after alcohol abstinence.T2 values for white matter,estimated by linear regression from 16 echoes of a CPGM sequence,however,showed no significant increase such as occurs in rehydration.This indicates,that alcohol-induced reversible brain atrophy cannot be attributed to fluctuation of free water in the brain only.

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